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TargetMol产品目录中 "

Obese Protein

"的结果
  • 抑制剂&激动剂
    5
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    5
    TargetMol | Recombinant_Protein
  • 多肽产品
    3
    TargetMol | Peptide_Products
  • YW1128
    T355472131223-64-6
    YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.References1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019). YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks. References1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).
    • 待估
    35日内发货
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    数量
  • trans-2-Hexadecenoyl-L-carnitine
    T3764026145-55-1
    trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite in urine[1]. [1]. Pengxiang She, et al. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013;8(3):e59443.
    • ¥ 3369
    待询
    规格
    数量
  • IGRP(206-214)
    T82079849069-99-4
    IGRP(206-214) 是一种肽,具有生物活性。它对应于非肥胖糖尿病型(NOD)小鼠中胰岛特异性葡萄糖6磷酸酶催化亚基相关蛋白(IGRP)的206-214残基,并能诱导此类小鼠产生糖尿病。此外,该肽对胰岛素原特异性T细胞有着特定的作用。
    • 待询
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  • CRF(6-33)(human)
    CRF (6-33)
    TP2047120066-38-8
    CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
    • ¥ 2990
    5日内发货
    规格
    数量
  • CRF (6-33) acetate(120066-38-8 free base)
    TP2047L
    CRF (6-33) acetate(120066-38-8 free base) 是促肾上腺皮质激素释放因子结合蛋白 (CRFBP) 抑制肽;从 CRFBP 中替换 CRF。在体内抑制肥胖大鼠的体重增加并增加运动活动。
    • ¥ 3610
    In stock
    规格
    数量